Adolescent brains remain particularly sensitive to inhalant exposure during critical development periods. Research published in the British Journal of Pharmacology found that chronic inhalant exposure during early adolescence results in greater structural and functional brain disturbances than exposure in adulthood, with subsequent impaired cognitive development affecting planning, attention, and impulse control.
Peak experimentation occurs between ages 12-17, with studies showing approximately 10% of adolescents experimenting with inhalants. Youth who initiate inhalant use before age 15 face 5-6 times higher addiction risk compared to those who begin later. The prefrontal cortex—responsible for judgment and impulse control—continues maturing through the mid-twenties, making younger users especially vulnerable to lasting neurological damage.

