7 Key Differences: Suboxone vs. Methadone
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7 Key Differences: Suboxone vs. Methadone
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7 Key Differences: Suboxone vs. Methadone

7 Key Differences: Suboxone vs. Methadone
Written by Seth Fletcher on September 8, 2024
Medical editor Dr. Karina Kowal
Last update: September 8, 2024

Suboxone and Methadone are widely recognized and accepted as medication-assisted treatments (MAT) for opioid dependency. But which one is most suitable for you? Understanding the qualities of each medication treatment can be a turning point in your recovery journey. Both medications have their merits, depending on efficacy, side effects, and accessibility.

Do you want to make an informed decision about which treatment suits you best? Let’s explore the fundamental distinctions that will help you choose wisely.

Key Takeaways

  • Personalized Treatment: The choice between Suboxone and Methadone depends on individual recovery needs.
  • Action Mechanism: Suboxone reduces misuse potential, while Methadone offers stronger effects for severe addiction.
  • Dependency Risk: Suboxone has a lower risk of dependency and milder withdrawal symptoms compared to Methadone.
  • Accessibility: Suboxone allows for home use, while Methadone requires daily clinic visits.
  • Side Effects: Methadone has a higher risk of respiratory issues, while Suboxone's naloxone component reduces this risk.

What Is Methadone?

Methadone is a crucial part of opioid addiction therapy. But what exactly is it, and how does it work? This long-acting opioid has been used for many years to manage withdrawal symptoms and prevent relapse.

what is methadone

Methadone binds to the same receptors in the brain as heroin, prescription, and other opioids, but it does so in a more controlled manner. Methadone has a longer duration of action and a milder impact than other opioids, which helps stabilize the brain's chemical balance. This stabilization prevents the cycle of craving and withdrawal, making it an effective treatment for opioid dependence.

Methadone helps patients reduce the urge to use drugs and alleviates the discomfort associated with withdrawal, giving them the opportunity to begin rebuilding their lives.

What Is Suboxone?

Understanding how Suboxone works is a powerful tool in your recovery journey. This knowledge empowers you, giving you a sense of control over your treatment. Suboxone is particularly beneficial for those battling opioid addiction because it instills confidence in managing the situation.

Suboxone is prescribed for the treatment of opioid dependence. It contains two main components: buprenorphine and naloxone.

Buprenorphine is a partial opioid agonist, meaning it binds to opioid receptors in the brain but only partially activates them. This helps curb cravings and withdrawal symptoms without producing the same high as other opioids. Naloxone, on the other hand, acts as an opioid antagonist, counteracting the effects of opioids if the medication is abused. The combination of these two components makes Suboxone a safer option with a lower risk of misuse.

Suboxone plays a crucial role in restoring the brain's chemical balance, which is often disrupted by opioid dependence. By doing so, it provides relief from cravings and withdrawal symptoms, helping individuals recover from addiction without the overpowering influence of the substance.

opioid maintenance therapy

Key Differences: Suboxone vs. Methadone

It’s important to understand that Suboxone and Methadone are not one-size-fits-all remedies. The benefits and risks associated with each will vary depending on the individual’s specific needs. The following comparison chart is provided to help you make an informed decision about your treatment.

The two drugs will be compared in terms of their mechanism of action, effectiveness, dependency potential, accessibility, cost, and methods of administration.

Suboxone vs Methadone key features:

AspectSuboxoneMethadone
Mechanism of actionPartial opioid agonist with an antagonist component (buprenorphine + naloxone). Limits euphoria and reduces misuse potential.Full opioid agonist. Provides stronger effects similar to opioids but controlled to reduce cravings.
EffectivenessEffective for mild to moderate opioid dependency. Reduces cravings and opioid addiction withdrawal symptoms while blocking the effects of other opioids.Effective for moderate to severe opioid addiction. Stronger in managing opioid addiction withdrawal symptoms and cravings, especially for long-term addiction.
Dependency riskLower risk of dependency due to its partial agonist nature. Less likely to cause a high or lead to abuse.Higher risk of dependency since it acts as a full opioid agonist, similar to other opioids, though in a regulated manner.
AccessibilityAvailable for take-home use after initial monitoring. Easier to access through doctors and clinics.Dispensed through specialized methadone clinics. Requires daily visits, making it less accessible for some individuals.
CostsTypically more affordable, especially with generic options. Covered by most insurance plans.Often more expensive, especially with regular clinic visits. Some coverage may vary depending on the province.
AdministrationAdministered as a sublingual tablet or film. Can be taken at home after the initial prescription phase.Administered as a liquid, typically requiring daily in-clinic dosing under supervision.

Suboxone and Methadone are both potent medications for opioid addiction, each with unique characteristics. The choice between the two should be based on your specific recovery needs, which can be determined through consultation with a healthcare professional. When considering Methadone vs. Suboxone, it’s essential to understand their differing effectiveness and roles in managing pain alongside addiction.

What Are the Side Effects of Methadone and Suboxone?

Understanding the potential side effects of Methadone and Suboxone is crucial in navigating opioid addiction treatment. Both medications play pivotal roles in restoring the body’s balance after illness onset, but they also come with their own set of side effects. A comprehensive understanding of these effects allows individuals and healthcare professionals to make informed decisions about the most suitable treatment options.

Methadone is highly effective in managing opioid dependence, but it comes with serious side effects. Common physical side effects include gastrointestinal issues, nausea, constipation, sweating, and weight gain. Other side effects include headaches, dizziness, drowsiness, and fatigue. Methadone can also affect mental health, potentially leading to mood swings, depression, or anxiety. Additionally, it can cause respiratory depression, particularly if administered incorrectly or combined with other substances with similar effects.

Suboxone, like Methadone, also has side effects, although they are generally milder. Physical side effects include headaches, nausea, constipation, sweating, and dizziness. Suboxone can also cause light-headedness or fainting, particularly when adjusting to the medication or during dosage changes. Psychological side effects may include mood changes, irritability, and anxiety or depressive symptoms, though these are often related to underlying conditions. Suboxone carries a lower risk of respiratory depression due to the presence of naloxone.

mental health

Here’s a comparative look at the side effects of Suboxone and Methadone:

Side EffectMethadoneSuboxone
Physical Side EffectsNausea, constipation, sweating, weight gain, drowsiness, fatigue.Headaches, nausea, constipation, sweating, dizziness.
Psychological Side EffectsMood swings, depression, anxiety.Mood changes, irritability, anxiety, depressive symptoms.
Respiratory EffectsRisk of respiratory depression.Lower risk of respiratory depression due to naloxone.

Both Methadone and Suboxone have side effects that can be managed with proper medical supervision. It’s important to report any side effects to your doctor to enhance the effectiveness of your treatment.

Addiction Treatment: Which Is More Difficult to Cure? 

Choosing between Suboxone and Methadone as a treatment for drug addiction involves more than just understanding their side effects. It also requires navigating the challenges associated with each.Suboxone is generally easier for most patients to manage, largely due to its partial agonist feature. It minimizes cravings and withdrawal symptoms with a lower risk of addiction. However, adjusting to Suboxone can be challenging as the body adapts to the new medication. The duration of Suboxone treatment is flexible and typically tailored to the individual, with some patients needing it for an extended period to maintain recovery. Suboxone’s lower potential for causing a high makes long-term recovery more feasible, reducing the risk of relapse.

methadone vs suboxone for pain

Methadone, while effective, presents a different set of challenges. As a full opioid agonist, Methadone can lead to physical dependency that is hard to overcome. Methadone withdrawal can be more intense and prolonged than Suboxone, making it more challenging for some patients. Treatment often requires frequent visits to a Methadone clinic, which can be a hurdle and lead to poor compliance.

The journey to recovery with Methadone can be long and complex, as some patients may become addicted to it, necessitating frequent changes in treatment.

Below, you can see a comparison of the challenges associated with each treatment:

FactorSuboxoneMethadone
WithdrawalGenerally less intense, but can be challenging initially.Often more intense and prolonged.
DependencyLower risk of dependency.Higher risk of dependency.
Treatment DurationVariable, tailored to individual needs; often shorter.Typically longer and requires frequent clinic visits.
Long-Term RecoveryGenerally more achievable due to lower risk of relapse.More challenging due to dependency risks and ongoing treatment needs.

Both Suboxone and Methadone have their pros and cons. The choice between them should be based on individual circumstances, the extent of addiction, and other personal treatment considerations. Consulting a healthcare professional is essential to make the best decision for long-term recovery.

Remember that visiting a drug rehab centre can be the best decision in this situation. 

FAQs

How do Suboxone and Methadone work for opioid addiction?

These medications help control a person’s addiction to opioids by restoring stable brain functioning, which reduces cravings and alleviates withdrawal symptoms. Suboxone is a combination of a partial opioid agonist, buprenorphine, which provides mild opioid effects, and naloxone, which makes the medication tamper-proof. Methadone, on the other hand, is a full opioid agonist that mimics the effects of opioids in a controlled manner, helping to manage cravings more effectively.

Which is a more helpful treatment: Suboxone or Methadone?

Both Suboxone and Methadone are effective treatments, each offering unique benefits. Suboxone is often preferred by individuals with mild to moderate addiction who can manage their treatment at home due to its mild effects and tamper-proof nature. Methadone, a full opioid agonist, is better suited for those with severe addiction, providing a stronger level of relief from withdrawal and cravings, although it requires more supervision.

What is the most common side effect of these medicines?

Common side effects of Suboxone include headaches, nausea, constipation, and dizziness. Methadone’s common side effects include nausea, drowsiness, constipation, and weight gain. Both medications can cause mood changes, although respiratory depression may be more common with Methadone.

Which of these treatments should I try, and how do I decide?

The decision to use Suboxone or Methadone should be made in consultation with a healthcare provider, considering your unique history, the severity of your addiction, and your personal needs. Factors such as the level of supervision you require, your risk of dependency, and your lifestyle should all be considered. Suboxone may be the best choice if you value flexibility in your treatment, while Methadone may be more suitable if you require stronger withdrawal relief and can commit to frequent clinic visits.

Can you switch from Suboxone to Methadone after you have started treatment?

Yes, it is possible to switch from Suboxone to Methadone, or vice versa, but this should always be done under the close supervision of a healthcare provider. Your provider will prescribe the new medication and adjust your dosages based on your response. It is crucial that the transition from one medication to the other is carefully monitored to ensure a safe and effective switch.

Certified Addiction Counsellor

Seth brings many years of professional experience working the front lines of addiction in both the government and privatized sectors.

Medicolegal Litigation Strategist/ Mediator

Dr. Karina Kowal is a Board Certified Physician specializing in insurance medicine and medicolegal expertise, holding certifications from the American Medical Association as a Certified Independent Medical Examiner. 

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